Genetic variations are associated with increased risk of breast cancer

Individuals with either of two genetic variations that lead to high serum levels of the cytokine leptin and to overexpression of leptin in fatty tissue, are more at risk of developing breast cancer than others.

individuals with a specific genetic variation (polymorphism) in the gene LEP that encodes for leptin, or a polymorphism in the gene LEPR, encoding for its receptor, have an increased risk of breast cancer.

Both polymorphisms could be used as markers to identify people at risk of breast cancer. As they are both associated with a shorter survival time they could potentially serve as predictors of prognosis.

BioMed Central | Abstract | 1471-2407-6-38 | Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma

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