Gene That Protects Against Kidney Stones

Yale School of Medicine researchers report in Nature Genetics this week that they have identified a gene whose function protects the body against kidney stones.

The research identifies a transporter, encoded by the gene, as a potential target for drugs to boost oxalate secretion in the gut and help prevent kidney stones, said Peter Aronson, M.D., professor of internal medicine and physiology and senior author of the study.

The most common type of kidney stones are composed of calcium oxalate. The transporter, known as SLC26A6, normally secretes oxalate into the intestine and prevents absorption of too much of the oxalate from the diet.

Yale Researchers Identify Gene That Protects Against Kidney Stones

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