8/13/2007

Alcohol, Tobacco and Genetics

The researchers investigated the genomic factors underlying alcohol and tobacco use in a cohort of 120 families ...

The researchers used a dense map (three haplotypes per cM; r2>0.4), generated by merging 58000 SNPs (single nucleotide polymorphisms) and 437 microsatellite markers, to identify sex-specific and non-specific linked and associated areas.

Summary of Results
The researchers reported the following results:

using the information from the questionnaires, the researchers found sex differences in prevalence of alcohol (17.3% in females and 38.3% in males) and tobacco (22.2% in females and 28% in males) use

a common locus (an identifiable location on a chromosome) for alcohol and tobacco was found on chromosome (chr) 1. Also on chr 1, in an area believed to be involved with diastolic blood pressure (DBP), they found a locus for smoking.

on chr 3, in the area identified as being involved with pre-math stress DBP, they found a locus for alcohol

on chr 4, inside gene GRID2, researchers found linked and associated SNPs for smoking moreover they found associated SNPs inside these gene for alcohol in males

female-specific candidate SNPs were found inside the HTR2C gene for smoking.

Newswise Medical News | Alcohol, Tobacco and Genetics: "etiology "

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